Jak3 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comJak3 Polyclonal Antibody for Mouse(Mus musculus)

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Index > タンパク質ライブラリ > Jak3(遺伝子名) > Mouse

Jak3 (遺伝子名),

Tyrosine-protein kinase JAK3 (タンパク質名 ), JAK3_MOUSE from NCBI database.

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一般的意見

抗原コメント

予測フラグメント

検証シーケンス

関連データベース

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遺伝子名:

Jak3;

タンパク質名:

Tyrosine-protein kinase JAK3;

エイリアス:

Janus kinase 3(JAK-3);

種:

Mouse (Mus musculus).

一般的意見

サブユニット:

Interacts with STAM2 and MYO18A. Interacts with SHB.

機能:

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

細胞内局在:

Endomembrane system Peripheral membrane protein Cytoplasm

タンパク質特性:

配列長:

1100

配列情報:

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3次元構造:

N/A

予測フラグメント:

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検証シーケンス:

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関連データベース

UniGene:

Mm.249645

Pfam:

PF07714

KEGG:

mmu:16453

SMR:

Q62137

String:

Q62137

Uniprot:

Q62137

FOR

ELISA Kit for Mouse Tyrosine-protein kinase JAK3

数。:

E0425r

価格:

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マニュアル:

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MSDS:

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仕様:

96T

レンジ:

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ELISA Kit for Mouse Tyrosine-protein kinase JAK3

数。:

E0425h

価格:

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マニュアル:

ビューマニュアル。

MSDS:

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仕様:

96T

レンジ:

Please sign in first.

ELISA Kit for Mouse Tyrosine-protein kinase JAK3

数。:

E0425m

価格:

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マニュアル:

ビューマニュアル。

MSDS:

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仕様:

96T

レンジ:

Please sign in first.

CLIA Kit for Mouse Tyrosine-protein kinase JAK3

数。:

U0425r

価格:

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マニュアル:

ビューマニュアル。

MSDS:

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仕様:

96T

レンジ:

Please sign in first.

CLIA Kit for Mouse Tyrosine-protein kinase JAK3

数。:

U0425m

価格:

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MSDS:

Please sign in first.

仕様:

96T

CLIA Kit for Mouse Tyrosine-protein kinase JAK3

数。:

U0425h

価格:

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MSDS:

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仕様:

96T

Polyclonal Antibody for Mouse Tyrosine-protein kinase JAK3

数。:

P0425Rb-r

価格:

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仕様:

40ug/0.2ml

Polyclonal Antibody for Mouse Tyrosine-protein kinase JAK3

数。:

P0425Rb-m

価格:

Please sign in first.

仕様:

40ug/0.2ml

Polyclonal Antibody for Mouse Tyrosine-protein kinase JAK3

数。:

P0425Rb-h

価格:

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仕様:

40ug/0.2ml

Monoclonal Antibody for Mouse Tyrosine-protein kinase JAK3